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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
05/12/2016 |
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Actualizado : |
09/10/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
VERDES, J. M.; MÁRQUEZ, M.; CALLIARI, A.; BATES, D.; MORAÑA, J. A.; GIMENO, E. J.; ODRIOZOLA, E.; GIANNITTI, F.; GUERRERO, F.; FIDALGO, L. E.; PUMAROLA, M. |
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Afiliación : |
JOSÉ MANUEL VERDES, Universidad de la República (UdelaR)/ Facultad de Veterinaria; MEC/ IIBCE (Instituto de Investigaciones de Ciencias Biológicas "Clemente Estable"); MERCEDES MÁRQUEZ, Universidad de Santiago de Compostela (USC); ALDO CALLIARI, Universidad de la República (UdelaR)/ Facultad de Veterinaria; MEC/ IIBCE (Instituto de Investigaciones de Ciencias Biológicas "Clemente Estable"); DANIEL BATES, Universidad de la República (UdelaR)/ Facultad de Veterinaria; JOSÉ ANTONIO MORAÑA, Universidad de la República (UdelaR)/ Facultad de Veterinaria; EDUARDO JUAN GIMENO, Universidad Nacional de la Plata (UNLP); ERNESTO ODRIOZOLA, INTA (Instituto Nacional de Tecnología Agropecuaria)- Balcarce; FEDERICO GIANNITTI, University of Minnesota, Saint Paul, MN, USA; INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FLORENTINA GUERRERO, Universidad de Santiago de Compostela (USC); LUIS EUSEBIO FIDALGO, Universidad de Santiago de Compostela (USC); MARTÍ PUMAROLA, Universitat Autònoma de Barcelona. |
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Título : |
A novel pathogenic mechanism for cerebellar lesions produced by Solanum bonariense in cattle. (Full Scientific Report) |
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Fecha de publicación : |
2015 |
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Fuente / Imprenta : |
Journal of Veterinary Diagnostic Investigation, 2015, v.27 (3): 278-286. |
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DOI : |
10.1177/1040638715582048 |
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Idioma : |
Inglés |
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Notas : |
Article history: First Published April 21, 2015. |
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Contenido : |
ABSTRACT.
Intoxication with Solanum bonariense in cattle causes cerebellar cortical degeneration with perikaryal vacuolation, axonal swelling, and death primarily of Purkinje cells, with accumulation of electron-dense residual storage bodies in membrane-bound vesicles. The pathogenesis of this disease is not fully understood. Previously, we proposed that inhibition of protein synthesis in Purkinje cells among other altered metabolic pathways could lead to cytoskeletal alterations, subsequently altering cell-specific axonal transport. In the present study, immunohistochemical and histochemical methods were used to identify neuronal cytoskeletal alterations and axonal loss, demyelination, and astrogliosis in the cerebellum of intoxicated bovines. Samples of cerebellum from 3 natural and 4 experimental cases and 2 control bovines were studied. Immunoreactivity against neurofilament (NF)-200KDa confirmed marked loss of Purkinje neurons, and phospho-NF protein, ?-tubulin, and affinity reaction against phalloidin revealed an altered perikaryal distribution of neuronal cytoskeletal proteins in the remaining Purkinje cells in intoxicated cattle. Reactive astrogliosis in every layer of the cerebellar cortex was also observed with anti?glial fibrillary acidic protein immunohistochemistry. In affected cattle, demyelination and axonal loss in the cerebellar white matter, as well as basket cell loss were demonstrated with Klüver?Barrera and Bielschowsky stains, respectively. Based on these results, we propose that neuronal cytoskeletal alterations with subsequent interference of the axonal transport in Purkinje cells may play a relevant role in the pathogenesis of this neurodegenerative disorder, and also that demyelination and axonal loss in the cerebellar white matter, as well as astrogliosis in the gray matter, likely occur secondarily to Purkinje cell degeneration and death.
© 2015 The Author(s). MenosABSTRACT.
Intoxication with Solanum bonariense in cattle causes cerebellar cortical degeneration with perikaryal vacuolation, axonal swelling, and death primarily of Purkinje cells, with accumulation of electron-dense residual storage bodies in membrane-bound vesicles. The pathogenesis of this disease is not fully understood. Previously, we proposed that inhibition of protein synthesis in Purkinje cells among other altered metabolic pathways could lead to cytoskeletal alterations, subsequently altering cell-specific axonal transport. In the present study, immunohistochemical and histochemical methods were used to identify neuronal cytoskeletal alterations and axonal loss, demyelination, and astrogliosis in the cerebellum of intoxicated bovines. Samples of cerebellum from 3 natural and 4 experimental cases and 2 control bovines were studied. Immunoreactivity against neurofilament (NF)-200KDa confirmed marked loss of Purkinje neurons, and phospho-NF protein, ?-tubulin, and affinity reaction against phalloidin revealed an altered perikaryal distribution of neuronal cytoskeletal proteins in the remaining Purkinje cells in intoxicated cattle. Reactive astrogliosis in every layer of the cerebellar cortex was also observed with anti?glial fibrillary acidic protein immunohistochemistry. In affected cattle, demyelination and axonal loss in the cerebellar white matter, as well as basket cell loss were demonstrated with Klüver?Barrera and Bielschowsky stains, respectively. Based on th... Presentar Todo |
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Palabras claves : |
BOVINE; CEREBELLAR DEGENERATION; CYTOSKELETAL DYSFUNCTION; PURKINJE CELLS; SOLANUM BONARIENSE. |
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Thesagro : |
BOVINOS. |
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Asunto categoría : |
L01 Ganadería |
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Marc : |
LEADER 02961naa a2200337 a 4500
001 1056202
005 2019-10-09
008 2015 bl uuuu u00u1 u #d
024 7 $a10.1177/1040638715582048$2DOI
100 1 $aVERDES, J. M.
245 $aA novel pathogenic mechanism for cerebellar lesions produced by Solanum bonariense in cattle. (Full Scientific Report)$h[electronic resource]
260 $c2015
500 $aArticle history: First Published April 21, 2015.
520 $aABSTRACT. Intoxication with Solanum bonariense in cattle causes cerebellar cortical degeneration with perikaryal vacuolation, axonal swelling, and death primarily of Purkinje cells, with accumulation of electron-dense residual storage bodies in membrane-bound vesicles. The pathogenesis of this disease is not fully understood. Previously, we proposed that inhibition of protein synthesis in Purkinje cells among other altered metabolic pathways could lead to cytoskeletal alterations, subsequently altering cell-specific axonal transport. In the present study, immunohistochemical and histochemical methods were used to identify neuronal cytoskeletal alterations and axonal loss, demyelination, and astrogliosis in the cerebellum of intoxicated bovines. Samples of cerebellum from 3 natural and 4 experimental cases and 2 control bovines were studied. Immunoreactivity against neurofilament (NF)-200KDa confirmed marked loss of Purkinje neurons, and phospho-NF protein, ?-tubulin, and affinity reaction against phalloidin revealed an altered perikaryal distribution of neuronal cytoskeletal proteins in the remaining Purkinje cells in intoxicated cattle. Reactive astrogliosis in every layer of the cerebellar cortex was also observed with anti?glial fibrillary acidic protein immunohistochemistry. In affected cattle, demyelination and axonal loss in the cerebellar white matter, as well as basket cell loss were demonstrated with Klüver?Barrera and Bielschowsky stains, respectively. Based on these results, we propose that neuronal cytoskeletal alterations with subsequent interference of the axonal transport in Purkinje cells may play a relevant role in the pathogenesis of this neurodegenerative disorder, and also that demyelination and axonal loss in the cerebellar white matter, as well as astrogliosis in the gray matter, likely occur secondarily to Purkinje cell degeneration and death. © 2015 The Author(s).
650 $aBOVINOS
653 $aBOVINE
653 $aCEREBELLAR DEGENERATION
653 $aCYTOSKELETAL DYSFUNCTION
653 $aPURKINJE CELLS
653 $aSOLANUM BONARIENSE
700 1 $aMÁRQUEZ, M.
700 1 $aCALLIARI, A.
700 1 $aBATES, D.
700 1 $aMORAÑA, J. A.
700 1 $aGIMENO, E. J.
700 1 $aODRIOZOLA, E.
700 1 $aGIANNITTI, F.
700 1 $aGUERRERO, F.
700 1 $aFIDALGO, L. E.
700 1 $aPUMAROLA, M.
773 $tJournal of Veterinary Diagnostic Investigation, 2015$gv.27 (3): 278-286.
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Treinta y Tres. |
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Fecha actual : |
11/03/2022 |
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Actualizado : |
01/09/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
SALVADOR-MONTOYA, C. A.; ELÍAS, S. G.; POPOFF, O. F.; ROBLEDO, G. L.; URCELAY, C.; GÓES-NETO, A.; MARTÍNEZ, S.; DRECHSLER-SANTOS, E. R. |
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Afiliación : |
CARLOS A. SALVADOR-MONTOYA, Laboratorio de Micología, Instituto de Botánica del Nordeste, IBONE, Universidad Nacional del Nordeste UNNE, Corrientes, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas—CONICET.; SAMUEL G. ELÍAS, Departamento de Botânica, Centro de Ciências Biológicas, Campus Universitário, Universidade Federal de Santa Catarina—UFSC, Brasil.; ORLANDO O. POPOFF, Laboratorio de Micología, Instituto de Botánica del Nordeste—IBONE, Universidad Nacional del Nordeste—UNNE, Corrientes, Argentina. /Consejo Nacional de Investigaciones Científicas y Técnicas—CONICET, Buenos Aires, Argentina; GERARDO L. ROBLEDO, Consejo Nacional de Investigaciones Científicas y Técnicas—CONICET, Buenos Aires , Argentina. / BioTecA3—Centro de Biotecnología Aplicada al Agro y Alimentos, Facultad de Ciencias Agropecuarias, Universidad Nacional de Córdoba, Argentina.; CARLOS URCELAY, Consejo Nacional de Investigaciones Científicas y Técnicas—CONICET, Buenos Aires, Argentina; ARISTÓTELES GÓES-NETO, Laboratório de Biologia Molecular e Computacional de Fungos (LBMCF), Departamento de Microbiologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais, Brasil.; SEBASTIÁN MARTÍNEZ KOPP, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ELISANDRO R. DRECHSLER-SANTOS, Departamento de Botânica, Centro de Ciências Biológicas, Campus Universitário, Universidade Federal de Santa Catarina—UFSC, Brasil. |
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Título : |
Neotropical studies on Hymenochaetaceae: Unveiling the diversity and endemicity of Phellinotus. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Journal of Fungi, 22 february 2022, vol. 8 (3) art.216. OPEN ACCESS. Doi: https://doi.org/10.3390/jof8030216 |
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DOI : |
10.3390/jof8030216 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: 15 January 2022 / Revised: 12 February 2022 / Accepted: 17 February 2022 / Published: 22 February 2022 |
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Contenido : |
Phellinotus, a neotropical genus of wood-decay fungi commonly found on living members of the Fabaceae family, was initially described as containing two species, P. neoaridus and P. piptadeniae. The members of this genus, along with six other well-established genera and some unresolved lineages, are the current representatives of the ?phellinotus clade?. On the other hand, based on a two-loci phylogenetic analysis, some entities/lineages of the ?phellinotus clade? have been found in Fomitiporella s.l. In this work, we performed four-loci phylogenetic analyses and based on our results the genera of the ?phellinotus clade? are shown to be monophyletic groups. In addition to the natural groups confirmed as different genera, morphological revisions, phylogenetic relationships, and host distribution of different specimens resembling P. neoaridus and P. piptadeniae revealed three new species in the Phellinotus genus, referred to here as P. magnoporatus, P. teixeirae and P. xerophyticus. Furthermore, for P. piptadeniae a narrower species concept was adopted with redefined morphological characters and a more limited distribution range. Both P. neoaridus and P. teixeirae have a distribution range restricted to seasonally dry tropical forests in South America. Additionally, based on detailed morphological revisions Phellinus badius, Phellinus resinaceus, and Phellinus scaber are transferred to the Phellinotus genus. The geographic distribution and host range of the genus are then discussed. View Full-Text MenosPhellinotus, a neotropical genus of wood-decay fungi commonly found on living members of the Fabaceae family, was initially described as containing two species, P. neoaridus and P. piptadeniae. The members of this genus, along with six other well-established genera and some unresolved lineages, are the current representatives of the ?phellinotus clade?. On the other hand, based on a two-loci phylogenetic analysis, some entities/lineages of the ?phellinotus clade? have been found in Fomitiporella s.l. In this work, we performed four-loci phylogenetic analyses and based on our results the genera of the ?phellinotus clade? are shown to be monophyletic groups. In addition to the natural groups confirmed as different genera, morphological revisions, phylogenetic relationships, and host distribution of different specimens resembling P. neoaridus and P. piptadeniae revealed three new species in the Phellinotus genus, referred to here as P. magnoporatus, P. teixeirae and P. xerophyticus. Furthermore, for P. piptadeniae a narrower species concept was adopted with redefined morphological characters and a more limited distribution range. Both P. neoaridus and P. teixeirae have a distribution range restricted to seasonally dry tropical forests in South America. Additionally, based on detailed morphological revisions Phellinus badius, Phellinus resinaceus, and Phellinus scaber are transferred to the Phellinotus genus. The geographic distribution and host range of the genus are then discu... Presentar Todo |
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Palabras claves : |
ENDEMIC FUNJI; PHYLOGENETIC LINEAGES; SDTF SPECIES; TAXONOMY; THREE NEW TAXA; XANTHOCROIC POLYPORES. |
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Asunto categoría : |
H20 Enfermedades de las plantas |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16652/1/Journal-Fungi-2022-Salvador-Montoya.pdf
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Marc : |
LEADER 02576naa a2200301 a 4500
001 1062822
005 2022-09-01
008 2022 bl uuuu u00u1 u #d
024 7 $a10.3390/jof8030216$2DOI
100 1 $aSALVADOR-MONTOYA, C. A.
245 $aNeotropical studies on Hymenochaetaceae$bUnveiling the diversity and endemicity of Phellinotus.$h[electronic resource]
260 $c2022
500 $aArticle history: Received: 15 January 2022 / Revised: 12 February 2022 / Accepted: 17 February 2022 / Published: 22 February 2022
520 $aPhellinotus, a neotropical genus of wood-decay fungi commonly found on living members of the Fabaceae family, was initially described as containing two species, P. neoaridus and P. piptadeniae. The members of this genus, along with six other well-established genera and some unresolved lineages, are the current representatives of the ?phellinotus clade?. On the other hand, based on a two-loci phylogenetic analysis, some entities/lineages of the ?phellinotus clade? have been found in Fomitiporella s.l. In this work, we performed four-loci phylogenetic analyses and based on our results the genera of the ?phellinotus clade? are shown to be monophyletic groups. In addition to the natural groups confirmed as different genera, morphological revisions, phylogenetic relationships, and host distribution of different specimens resembling P. neoaridus and P. piptadeniae revealed three new species in the Phellinotus genus, referred to here as P. magnoporatus, P. teixeirae and P. xerophyticus. Furthermore, for P. piptadeniae a narrower species concept was adopted with redefined morphological characters and a more limited distribution range. Both P. neoaridus and P. teixeirae have a distribution range restricted to seasonally dry tropical forests in South America. Additionally, based on detailed morphological revisions Phellinus badius, Phellinus resinaceus, and Phellinus scaber are transferred to the Phellinotus genus. The geographic distribution and host range of the genus are then discussed. View Full-Text
653 $aENDEMIC FUNJI
653 $aPHYLOGENETIC LINEAGES
653 $aSDTF SPECIES
653 $aTAXONOMY
653 $aTHREE NEW TAXA
653 $aXANTHOCROIC POLYPORES
700 1 $aELÍAS, S. G.
700 1 $aPOPOFF, O. F.
700 1 $aROBLEDO, G. L.
700 1 $aURCELAY, C.
700 1 $aGÓES-NETO, A.
700 1 $aMARTÍNEZ, S.
700 1 $aDRECHSLER-SANTOS, E. R.
773 $tJournal of Fungi, 22 february 2022, vol. 8 (3) art.216. OPEN ACCESS. Doi: https://doi.org/10.3390/jof8030216
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